|
KMID : 0608520100160010141
|
|
Korean Journal of Oriental Medicine
2010 Volume.16 No. 1 p.141 ~ p.147
|
|
|
Methanolic extract from the root of Bupleuri falcatum L. attenuates cocaine-induced c-Fos expression in rat brain
|
|
Choi Seong-Hun
Yang Chae-Ha
Ku Sae-Kwang
Han Chang-Hyun
|
|
|
Abstract
|
|
|
Objectives : The aim of present study is to examine the effect of methanolic extract from the root of Bupleurum falcatum L. (BF) on acute cocaine-induced c-Fos expression in the rat caudate putamen (CPu), a major dopaminergic terminal.
Methods : Male Sprague-Dawley rats were subjected to an intraperitoneal injection with either cocaine hydrochloride (20 ㎎/㎏) or saline 30 min after an administration of either extract of BF (100 ㎎/㎏, i.p.) or vehicle. Animals were sacrificed 2 hr after treatment with cocaine or saline for immunohistochemistry. Quantification of brain slices was examined for c-Fos positive nuclei using light microscopy.
Results : Pretreatment with BF significantly attenuated cocaine-induced c-Fos expression in the rat CPu.
Conclusions : This finding suggests that BF has the inhibitory effect on cocaine-induced c-Fos expression in the rat CPu via possibly modulating the activities of central dopaminergic systems.
|
|
|
KEYWORD
|
|
|
Bupleurum falcatum, Cocaine, C-Fos, The caudate putamen
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|